Hi Colleague,
For many analytical scientists, HPLC method development can become an endless cycle of “just one more experiment.”
But according to John Dolan of LC Resources and Analytical Training Solutions, one of the biggest pitfalls in method development is chasing the perfect separation instead of building a method that is simply fit for purpose.
He calls this concept “adequatization” — knowing when a method is robust enough for the application and having the discipline to stop optimizing.
It’s a small shift in mindset, but one that can save significant time and resources in the lab.
We recently shared a deeper breakdown of Dolan’s approach, including practical insights on QbD, robustness, and identifying the critical peak pair.
👉 Read the full article here >>
